Menopause & Weight – Why Fat Distribution and Metabolism Change

“My trousers suddenly didn’t fit anymore – even though I wasn’t eating more or exercising less.” This is a common sentiment shared by many women in midlife who face unexpected weight gain. Even more frustrating: familiar strategies like eating less or moving more seem to have less effect than they used to.

Over 50% of women gain weight during menopause. Long-term studies show that this amounts to an average of 1.5 kg per year – leading to up to 10 kg by the end of the menopausal transition. But it's not just the weight itself – it's also about how fat is distributed: shifting from hips and thighs toward the abdominal area.

This development isn't only a cosmetic issue – it has real health implications. At the same time, our perception of body image, weight, and beauty is heavily influenced by external ideals. Advertising, social media, and societal expectations set standards that rarely reflect real life. What’s important: there is no such thing as a single ideal figure. What matters is how you feel – and what your body needs to stay healthy.

Hormonal Changes

During menopause, estrogen levels steadily decline. This affects where and how fat is stored:

• Fat distribution: Before menopause, fat tends to accumulate in the hips and thighs – the so-called gynoid pattern. With decreasing estrogen, fat shifts to the abdomen – the so-called android pattern, which carries higher health risks.

• Fat processing: Estrogen also affects how efficiently the body metabolizes dietary fat. When estrogen drops, fat is more likely to be stored than used.

Reduced Insulin Sensitivity – A Silent Risk

Estrogen enhances insulin sensitivity – meaning it helps glucose enter the cells. As estrogen declines, this sensitivity can decrease. The consequences:

• Glucose remains in the bloodstream instead of being used for energy.

• More fat is stored, especially in the abdominal area.

• Fatigue and sugar cravings can increase.

Over time, this can develop into metabolic syndrome – a combination of abdominal fat, high blood pressure, and impaired glucose and fat metabolism. This significantly increases the risk of type 2 diabetes and cardiovascular disease.

Loss of Muscle Mass and Reduced Physical Activity

As we age, muscle mass naturally decreases – a process exacerbated by hormonal changes. Simultaneously, many women in midlife reduce physical activity, due to work demands, caregiving responsibilities, or joint pain.

• Less muscle = fewer calories burned at rest.

• Basal metabolic rate drops – by around 200–400 kcal/day in your 60s compared to your 20s.

Stress, Sleep, and Cortisol

Menopause often brings sleep disturbances and increased stress – from career transitions, caregiving, or internal unrest.

Chronic stress raises cortisol levels – a hormone that:

• Promotes abdominal fat storage

• Increases cravings for sugar and fat

• Disrupts hunger regulation

Hormonal changes during menopause affect fundamental processes – particularly fat and glucose metabolism. Not only the amount of fat but also its distribution and activity matter, especially abdominal (visceral) fat. A key element is blood lipid levels:

• LDL (low-density lipoprotein): Often called “bad cholesterol” – it can accumulate in arteries and increase the risk of atherosclerosis, a precursor to heart attack and stroke.

• HDL (high-density lipoprotein): Known as “good cholesterol” – it helps remove excess LDL from the blood and protects blood vessels.

• Triglycerides: A form of fat in the blood, often elevated with high sugar and fat intake – an independent risk factor for heart disease.

• Lipoprotein(a): A genetically determined blood lipid that independently raises heart disease risk.

These values are influenced by estrogen levels, lifestyle, and genetics. During menopause, LDL and triglycerides tend to rise, while HDL may fall – often without symptoms. That’s why regular blood testing is so important.

Moderate weight gain isn't necessarily harmful. What matters is where the fat accumulates and how metabolic markers like glucose, lipids, and blood pressure develop. Visceral fat, which surrounds internal organs, is particularly concerning.

• Increased cardiovascular risk: Visceral fat promotes inflammation, raises blood pressure, and contributes to artery plaque formation – increasing the risk of heart attack and stroke.

• Metabolic syndrome: This is diagnosed when several risk factors occur together – such as abdominal fat, high blood pressure, high triglycerides, and impaired glucose tolerance.

• Emotional impact: Physical changes can affect self-image, trigger shame, or lead to disordered eating – a vicious cycle of frustration, dieting, and weight fluctuations.

While you can't stop menopause, you can influence how it affects your body. The goal is not a specific weight, but metabolic balance, well-being, and self-care.

1. Build Health Literacy

Understanding your body helps you make informed decisions – and protects you from unrealistic beauty ideals. Knowing your options gives you back a sense of control.

2. Monitor Key Health Markers

Regular check-ups help detect silent risks early:

• Blood lipids: LDL, HDL, triglycerides, lipoprotein(a)

• Glucose: fasting glucose, HbA1c

• Thyroid function: TSH – low thyroid can promote weight gain

• Blood pressure

• Cardiovascular diagnostics: e.g., carotid ultrasound (carotid duplex) if risk factors exist

3. Realistic, Effective Nutrition

A balanced, anti-inflammatory diet supports weight and hormonal balance:

• Healthy fats: from avocado, olive oil, nuts, and seeds

• More fiber: from whole grains, legumes, and vegetables

• Less sugar & refined carbs

• Structured meals instead of constant snacking

• Stay hydrated – it supports metabolism and satiety

4. Movement – Four Pillars of Activity

Physical activity is key to managing weight, hormones, and metabolism:

• Everyday movement: walk, take the stairs

• Endurance: at least 150 minutes per week – walking, cycling, swimming

• Strength training: 2–3 times per week – maintains muscle and boosts metabolism

• Balance and mobility: yoga, Tai Chi, or targeted exercises – especially for fall prevention

5. Manage Stress and Sleep

Chronic stress and poor sleep disrupt appetite and metabolism:

• Stress reduction: breathing techniques, meditation, creative breaks

• Sleep hygiene: consistent bedtime, no screens before bed, relaxing rituals

Practice self-compassion: Perfection is not the goal – seeking support is strength, not weakness.

Many women wonder if MHT helps with weight gain – or weight loss. Current evidence shows no significant effect on weight itself.

However, studies suggest that MHT may limit the shift toward visceral fat. Estrogen therapy can help slow abdominal fat accumulation and preserve muscle mass – which helps maintain basal metabolic rate.

The decision for or against MHT should always be made with a healthcare provider. Factors include:

• Severity of symptoms

• Medical history

• Family risks (e.g., for breast cancer or thrombosis)

MHT is not prescribed to manage weight – but it can indirectly support metabolic stability and quality of life.

When lifestyle changes aren't enough, medication may be an option – especially with medical reasons for weight reduction.

GLP-1 Agonists like Wegovy®, Ozempic®, Mounjaro®

Originally developed for type 2 diabetes, these medications are highly effective for obesity:

• Enhance satiety

• Reduce appetite

• Slow gastric emptying

• Stabilize blood sugar

Studies show many users lose 10% or more of their body weight in just months.

What you should know:

• Weekly injections

• Only approved for certain BMI thresholds

• Side effects: nausea, fullness, diarrhea (often temporary)

• Effectiveness depends on concurrent lifestyle changes

Important: Studies show weight often returns to near baseline within 12–24 months after stopping the medication – unless long-term habits around diet, exercise, and muscle building are implemented.

These medications can help you start – but they don’t replace healthy living. Book an appointment with your Evela expert here and receive solutions tailored to you.

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• British Menopause Society. (2023). Menopause: Nutrition and weight gain. https://thebms.org.uk/wp-content/uploads/2023/06/19-BMS-TfC-Menopause-Nutrition-and-Weight-Gain-JUNE2023-A.pdf

• Liedtke S., Schmidt M.E., Vrieling A., Lukanova A., Becker S., Kaaks R., Zaineddin A.K., Buck K., Benner A., Chang-Claude J., et al. Postmenopausal sex hormones in relation to body fat distribution. Obesity. 2012;20:1088–1095. doi: 10.1038/oby.2011.383. [DOI] [PubMed] [Google Scholar]

• Lodish H. et al. Molecular Cell Biology. 8th edition. Chapter 18: Lipid Metabolism. W.H. Freeman and Company.

• Santosa S, Jensen MD. "The Sexual Dimorphism of Lipid Kinetics in Humans." Front Endocrinol (Lausanne). 2015;6:103. doi:10.3389/fendo.2015.00103

• Carr MC. "The emergence of the metabolic syndrome with menopause." J Clin Endocrinol Metab. 2003;88(6):2404-2411.

• D'Eon TM et al. "Estrogen regulation of adiposity and fuel partitioning. Evidence of genomic and non-genomic regulation of lipogenic and oxidative pathways." J Biol Chem. 2005;280(43):35983-35991.

• Cui J et al. "Menopausal transition and risk of cardiovascular disease: a meta-analysis of prospective cohort studies." J Am Heart Assoc. 2020;9(15):e015550.

• Gambacciani M, Ciaponi M, Cappagli B, De Simone L, Orlandi R, Genazzani AR. Prospective evaluation of body weight and body fat distribution in early postmenopausal women with and without hormonal replacement therapy. Maturitas. 2001 Aug 25;39(2):125-32. doi: 10.1016/s0378-5122(01)00194-3. PMID: 11514111.

• Berg S, Stickle H, Rose SJ, Nemec EC. Discontinuing glucagon-like peptide-1 receptor agonists and body habitus: A systematic review and meta-analysis. Obes Rev. 2025 Apr 4:e13929. doi: 10.1111/obr.13929. Epub ahead of print. PMID: 40186344.